Evaluation of Pharmacobezoar Formation from Suspensions of Spray-Dried Amorphous Solid Dispersions: An MRI Study in Rats

Spray-dried amorphous solid dispersions of new chemical entities and pH-dependent soluble polymer hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were found to form solid agglomerates in the gastrointestinal tract of rodents after oral administration. These agglomerates, referring to descr...

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Detalles Bibliográficos
Autores principales: Gierke, Hannes, Mouchantat, Susan, Berg, Sabine, Grimm, Michael, Hadlich, Stefan, Kromrey, Marie-Luise, Nolte, Thomas, Pfrommer, Teresa, Rönnpagel, Vincent, Rump, Adrian, Schaefer, Kerstin, Willmann, Ann-Cathrin, Weitschies, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052685/
https://www.ncbi.nlm.nih.gov/pubmed/36986751
http://dx.doi.org/10.3390/pharmaceutics15030887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052685/
https://www.ncbi.nlm.nih.gov/pubmed/36986751
http://dx.doi.org/10.3390/pharmaceutics15030887

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