Treatment with the Glycosphingolipid Modulator THI Rescues Myelin Integrity in the Striatum of R6/2 HD Mice

Huntington’s disease is one of the most common dominantly inherited neurodegenerative disorders caused by an expansion of a polyglutamine (polyQ) stretch in the N-terminal region of huntingtin (Htt). Among all the molecular mechanisms, affected by the mutation, emerging evidence proposes glycosphing...

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Detalles Bibliográficos
Autores principales: Pepe, Giuseppe, Lenzi, Paola, Capocci, Luca, Marracino, Federico, Pizzati, Ludovica, Scarselli, Pamela, Di Pardo, Alba, Fornai, Francesco, Maglione, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053002/
https://www.ncbi.nlm.nih.gov/pubmed/36983032
http://dx.doi.org/10.3390/ijms24065956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053002/
https://www.ncbi.nlm.nih.gov/pubmed/36983032
http://dx.doi.org/10.3390/ijms24065956

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