Improving Properties of Podophyllic Aldehyde-Derived Cyclolignans: Design, Synthesis and Evaluation of Novel Lignohydroquinones, Dual-Selective Hybrids against Colorectal Cancer Cells

New lignohydroquinone conjugates (L-HQs) were designed and synthesized using the hybridization strategy, and evaluated as cytotoxics against several cancer cell lines. The L-HQs were obtained from the natural product podophyllotoxin and some semisynthetic terpenylnaphthohydroquinones, prepared from...

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Detalles Bibliográficos
Autores principales: Hernández, Ángela-Patricia, Díez, Paula, García, Pablo A., Pérez-Andrés, Martín, Veselinova, Anzhela, Jambrina, Pablo G., San Feliciano, Arturo, Díez, David, Fuentes, Manuel, Castro, Mᵃ Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053213/
https://www.ncbi.nlm.nih.gov/pubmed/36986749
http://dx.doi.org/10.3390/pharmaceutics15030886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053213/
https://www.ncbi.nlm.nih.gov/pubmed/36986749
http://dx.doi.org/10.3390/pharmaceutics15030886

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