Cargando…

Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

The IFN system constitutes a powerful antiviral defense machinery. Consequently, effective IFN responses protect against severe COVID-19 and exogenous IFNs inhibit SARS-CoV-2 in vitro. However, emerging SARS-CoV-2 variants of concern (VOCs) may have evolved reduced IFN sensitivity. Here, we determin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nchioua, Rayhane, Schundner, Annika, Klute, Susanne, Koepke, Lennart, Hirschenberger, Maximilian, Noettger, Sabrina, Fois, Giorgio, Zech, Fabian, Graf, Alexander, Krebs, Stefan, Braubach, Peter, Blum, Helmut, Stenger, Steffen, Kmiec, Dorota, Frick, Manfred, Kirchhoff, Frank, Sparrer, Konstantin MJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053418/ https://www.ncbi.nlm.nih.gov/pubmed/36977594 http://dx.doi.org/10.26508/lsa.202201745

Ejemplares similares

Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization
por: Pastorio, Chiara, et al.
Publicado: (2023)

SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells
por: Nchioua, Rayhane, et al.
Publicado: (2022)

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes
por: Nchioua, Rayhane, et al.
Publicado: (2022)

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
por: Pastorio, Chiara, et al.
Publicado: (2022)

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?
por: Jung, Christoph, et al.
Publicado: (2022)

Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2
por: Xie, Qinya, et al.
Publicado: (2023)

Manipulation of autophagy by SARS-CoV-2 proteins
por: Koepke, Lennart, et al.
Publicado: (2021)

Cellular Factors Targeting HIV-1 Transcription and Viral RNA Transcripts
por: Nchioua, Rayhane, et al.
Publicado: (2020)

Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins
por: Hirschenberger, Maximilian, et al.
Publicado: (2021)

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans
por: Nchioua, Rayhane, et al.
Publicado: (2020)

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities
por: Hayn, Manuel, et al.
Publicado: (2021)

Near-Native Visualization of SARS-CoV-2 Induced Membrane Remodeling and Virion Morphogenesis
por: Bergner, Tim, et al.
Publicado: (2022)

Spike residue 403 affects binding of coronavirus spikes to human ACE2
por: Zech, Fabian, et al.
Publicado: (2021)

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein
por: Kmiec, Dorota, et al.
Publicado: (2020)

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
por: Prelli Bozzo, Caterina, et al.
Publicado: (2021)

Interferon antagonists encoded by SARS-CoV-2 at a glance
por: Lee, Jung-Hyun, et al.
Publicado: (2022)

An improved method for high-throughput quantification of autophagy in mammalian cells
por: Koepke, Lennart, et al.
Publicado: (2020)

Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests
por: Osterman, Andreas, et al.
Publicado: (2022)

BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants
por: Rössler, Annika, et al.
Publicado: (2022)

Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5
por: Krenn, Franziska, et al.
Publicado: (2023)

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
por: Wang, Qingxing, et al.
Publicado: (2023)

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor
por: Zech, Fabian, et al.
Publicado: (2023)

CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin
por: Hirschenberger, Maximilian, et al.
Publicado: (2021)

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections
por: Hirschenberger, Maximilian, et al.
Publicado: (2021)

Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections
por: Pedersen, Rune M., et al.
Publicado: (2022)

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
por: Wettstein, Lukas, et al.
Publicado: (2021)

Vaccine- and Breakthrough Infection-Elicited Pre-Omicron Immunity More Effectively Neutralizes Omicron BA.1, BA.2, BA.4 and BA.5 Than Pre-Omicron Infection Alone
por: Santos da Silva, Eveline, et al.
Publicado: (2023)

Insights Into Development and Progression of Idiopathic Pulmonary Fibrosis From Single Cell RNA Studies
por: Nemeth, Julia, et al.
Publicado: (2020)

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
por: Thoms, Matthias, et al.
Publicado: (2020)

Antibody Response to Omicron BA.4–BA.5 Bivalent Booster
por: Wang, Qian, et al.
Publicado: (2023)

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
por: Khan, Khadija, et al.
Publicado: (2022)

Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5
por: Kawasuji, Hitoshi, et al.
Publicado: (2023)

Neutralizing activity against Omicron BA.5 after tixagevimab/cilgavimab administration comparable to those after Omicron BA.1/BA.2 breakthrough infections
por: Yang, Jinyoung, et al.
Publicado: (2023)

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
por: Cao, Yunlong, et al.
Publicado: (2022)

A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5
por: Duan, Minrun, et al.
Publicado: (2023)

HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression
por: Srinivasachar Badarinarayan, Smitha, et al.
Publicado: (2020)

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
por: Tripathi, Utkarsh, et al.
Publicado: (2021)

Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids
por: Krüger, Jana, et al.
Publicado: (2020)

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins
por: Bosso, Matteo, et al.
Publicado: (2021)

Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera
por: Wang, Xun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_13f9j5hk3kougetg3m97veva2h