Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, be...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053952/ https://www.ncbi.nlm.nih.gov/pubmed/36985617 http://dx.doi.org/10.3390/molecules28062646 |
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author | Kostić, Kristina Brborić, Jasmina Delogu, Giovanna Simić, Milena R. Samardžić, Stevan Maksimović, Zoran Dettori, Maria Antonietta Fabbri, Davide Kotur-Stevuljević, Jelena Saso, Luciano |
author_facet | Kostić, Kristina Brborić, Jasmina Delogu, Giovanna Simić, Milena R. Samardžić, Stevan Maksimović, Zoran Dettori, Maria Antonietta Fabbri, Davide Kotur-Stevuljević, Jelena Saso, Luciano |
author_sort | Kostić, Kristina |
collection | PubMed |
description | A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (p < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (p < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components. |
format | Online Article Text |
id | pubmed-10053952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100539522023-03-30 Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls Kostić, Kristina Brborić, Jasmina Delogu, Giovanna Simić, Milena R. Samardžić, Stevan Maksimović, Zoran Dettori, Maria Antonietta Fabbri, Davide Kotur-Stevuljević, Jelena Saso, Luciano Molecules Article A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (p < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (p < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components. MDPI 2023-03-14 /pmc/articles/PMC10053952/ /pubmed/36985617 http://dx.doi.org/10.3390/molecules28062646 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kostić, Kristina Brborić, Jasmina Delogu, Giovanna Simić, Milena R. Samardžić, Stevan Maksimović, Zoran Dettori, Maria Antonietta Fabbri, Davide Kotur-Stevuljević, Jelena Saso, Luciano Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title_full | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title_fullStr | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title_full_unstemmed | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title_short | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
title_sort | antioxidant activity of natural phenols and derived hydroxylated biphenyls |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053952/ https://www.ncbi.nlm.nih.gov/pubmed/36985617 http://dx.doi.org/10.3390/molecules28062646 |
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