Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls

A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, be...

Descripción completa

Detalles Bibliográficos
Autores principales: Kostić, Kristina, Brborić, Jasmina, Delogu, Giovanna, Simić, Milena R., Samardžić, Stevan, Maksimović, Zoran, Dettori, Maria Antonietta, Fabbri, Davide, Kotur-Stevuljević, Jelena, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053952/
https://www.ncbi.nlm.nih.gov/pubmed/36985617
http://dx.doi.org/10.3390/molecules28062646
_version_ 1785015536128622592
author Kostić, Kristina
Brborić, Jasmina
Delogu, Giovanna
Simić, Milena R.
Samardžić, Stevan
Maksimović, Zoran
Dettori, Maria Antonietta
Fabbri, Davide
Kotur-Stevuljević, Jelena
Saso, Luciano
author_facet Kostić, Kristina
Brborić, Jasmina
Delogu, Giovanna
Simić, Milena R.
Samardžić, Stevan
Maksimović, Zoran
Dettori, Maria Antonietta
Fabbri, Davide
Kotur-Stevuljević, Jelena
Saso, Luciano
author_sort Kostić, Kristina
collection PubMed
description A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (p < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (p < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components.
format Online
Article
Text
id pubmed-10053952
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100539522023-03-30 Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls Kostić, Kristina Brborić, Jasmina Delogu, Giovanna Simić, Milena R. Samardžić, Stevan Maksimović, Zoran Dettori, Maria Antonietta Fabbri, Davide Kotur-Stevuljević, Jelena Saso, Luciano Molecules Article A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (p < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (p < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components. MDPI 2023-03-14 /pmc/articles/PMC10053952/ /pubmed/36985617 http://dx.doi.org/10.3390/molecules28062646 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kostić, Kristina
Brborić, Jasmina
Delogu, Giovanna
Simić, Milena R.
Samardžić, Stevan
Maksimović, Zoran
Dettori, Maria Antonietta
Fabbri, Davide
Kotur-Stevuljević, Jelena
Saso, Luciano
Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title_full Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title_fullStr Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title_full_unstemmed Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title_short Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
title_sort antioxidant activity of natural phenols and derived hydroxylated biphenyls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053952/
https://www.ncbi.nlm.nih.gov/pubmed/36985617
http://dx.doi.org/10.3390/molecules28062646
work_keys_str_mv AT kostickristina antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT brboricjasmina antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT delogugiovanna antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT simicmilenar antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT samardzicstevan antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT maksimoviczoran antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT dettorimariaantonietta antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT fabbridavide antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT koturstevuljevicjelena antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls
AT sasoluciano antioxidantactivityofnaturalphenolsandderivedhydroxylatedbiphenyls