Effect of Dexamethasone on Abiraterone Pharmacokinetics in Mice: Determined by LC/MS Analysis

Background: Abiraterone acetate is a cytochrome P450 17A1 (CYP17A1) inhibitor that is indicated for use in both castration-resistant and castration-sensitive prostate cancer patients. To manage the mineralocorticoid effects of CYP17A1 inhibition, a glucocorticoid such as dexamethasone is co-administ...

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Detalles Bibliográficos
Autores principales: Deb, Subrata, Ben-Eltriki, Mohamed, Adomat, Hans, Chin, Mei Y., Tomlinson Guns, Emma S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053955/
https://www.ncbi.nlm.nih.gov/pubmed/36976310
http://dx.doi.org/10.3390/medicines10030021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053955/
https://www.ncbi.nlm.nih.gov/pubmed/36976310
http://dx.doi.org/10.3390/medicines10030021

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