Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

Lipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid-raft microdomains are essential components of phagolysosomal membranes of macrophages and depend on flotillins. Genetic deletion of flotillins...

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Detalles Bibliográficos
Autores principales: Schmidt, Franziska, Thywißen, Andreas, Goldmann, Marie, Cunha, Cristina, Cseresnyés, Zoltán, Schmidt, Hella, Rafiq, Muhammad, Galiani, Silvia, Gräler, Markus H., Chamilos, Georgios, Lacerda, João F., Campos, António, Eggeling, Christian, Figge, Marc Thilo, Heinekamp, Thorsten, Filler, Scott G., Carvalho, Agostinho, Brakhage, Axel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054021/
https://www.ncbi.nlm.nih.gov/pubmed/32814035
http://dx.doi.org/10.1016/j.celrep.2020.108017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054021/
https://www.ncbi.nlm.nih.gov/pubmed/32814035
http://dx.doi.org/10.1016/j.celrep.2020.108017

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