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FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

BACKGROUND: Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was designed to investigate the functional significance of FBXW7 loss of function and...

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Detalles Bibliográficos
Autores principales: Pan, Yunzhi, Liu, Jing, Gao, Yingyin, Guo, Yuqing, Wang, Changxing, Liang, Zhipan, Wu, Meiying, Qian, Yulan, Li, Yinyan, Shen, Jingyi, Lu, Chenchen, Ma, Sai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054043/
https://www.ncbi.nlm.nih.gov/pubmed/36991467
http://dx.doi.org/10.1186/s13046-023-02630-3