Cargando…

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

BACKGROUND: Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was designed to investigate the functional significance of FBXW7 loss of function and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Yunzhi, Liu, Jing, Gao, Yingyin, Guo, Yuqing, Wang, Changxing, Liang, Zhipan, Wu, Meiying, Qian, Yulan, Li, Yinyan, Shen, Jingyi, Lu, Chenchen, Ma, Sai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054043/ https://www.ncbi.nlm.nih.gov/pubmed/36991467 http://dx.doi.org/10.1186/s13046-023-02630-3

Ejemplares similares

[Retracted] miR‑25 promotes metastasis via targeting FBXW7 in esophageal squamous cell carcinoma
por: Hua, Ye, et al.
Publicado: (2023)

FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells
por: An, Hyun-Jung, et al.
Publicado: (2022)

TAK1 Phosphorylates RASSF9 and Inhibits Esophageal Squamous Tumor Cell Proliferation by Targeting the RAS/MEK/ERK Axis
por: Shi, Hui, et al.
Publicado: (2021)

FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma
por: Qiu, Bo, et al.
Publicado: (2023)

Clinical significance of FBXW7 loss of function in human cancers
por: Fan, Jingyi, et al.
Publicado: (2022)

Fbxw11 impairs the repopulation capacity of hematopoietic stem/progenitor cells
por: Wang, Lina, et al.
Publicado: (2022)

A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media
por: Aoki, Kazuhiro, et al.
Publicado: (2013)

ERK expression and its correlation with STAT1 in esophageal squamous cell carcinoma
por: Wang, Hu, et al.
Publicado: (2017)

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15
por: Li, Ningning, et al.
Publicado: (2015)

S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis
por: Feng, Xiujing, et al.
Publicado: (2013)

Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis
por: Chen, Xin, et al.
Publicado: (2020)

The Role of FBXW7 in Gynecologic Malignancies
por: Di Fiore, Riccardo, et al.
Publicado: (2023)

Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor
por: Hernandez, Maria Aguilar, et al.
Publicado: (2016)

Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1
por: Lai, Shenshen, et al.
Publicado: (2016)

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
por: Bardwell, A Jane, et al.
Publicado: (2022)

Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma
por: Kurashige, J, et al.
Publicado: (2012)

MiR-223 promotes oral squamous cell carcinoma proliferation and migration by regulating FBXW7
por: Jiang, Lihua, et al.
Publicado: (2019)

Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma
por: Zhu, Zhengfei, et al.
Publicado: (2015)

Expression and phosphorylation of stathmin correlate with cell migration in esophageal squamous cell carcinoma
por: LIU, FEI, et al.
Publicado: (2013)

Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer
por: Kirzinger, Morgan W. B., et al.
Publicado: (2019)

MYC is a critical target of FBXW7
por: Sato, Mai, et al.
Publicado: (2014)

A widely used pan-isoform-FBXW7 antibody used in cell cycle studies does not detect FBXW7
por: Ennis, Hannah, et al.
Publicado: (2023)

Autophagy proteins regulate ERK phosphorylation
por: Martinez-Lopez, Nuria, et al.
Publicado: (2013)

Phase plane dynamics of ERK phosphorylation
por: Shvartsman, Stanislav Y., et al.
Publicado: (2023)

Foretinib Enhances the Radiosensitivity in Esophageal Squamous Cell Carcinoma by Inhibiting Phosphorylation of c-Met
por: Chen, Guang-Zong, et al.
Publicado: (2017)

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma
por: Zheng, Zhen-Yuan, et al.
Publicado: (2022)

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma
por: Kumakura, Yuji, et al.
Publicado: (2017)

GSK3β-SCF(FBXW7α) mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
por: Garvin, Alexander J, et al.
Publicado: (2019)

Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity
por: Ko, Yeon Uk, et al.
Publicado: (2019)

Loss of CDC4/FBXW7 in Gastric Carinoma
por: Milne, A. N., et al.
Publicado: (2010)

ERK Phosphorylation Regulates Sleep and Plasticity in Drosophila
por: Vanderheyden, William M., et al.
Publicado: (2013)

Phosphorylation of ERK5 on Thr732 Is Associated with ERK5 Nuclear Localization and ERK5-Dependent Transcription
por: Honda, Takuto, et al.
Publicado: (2015)

Raltitrexed Enhances the Antitumor Effect of Apatinib in Human Esophageal Squamous Carcinoma Cells via Akt and Erk Pathways
por: Zhen, Hongchao, et al.
Publicado: (2020)

Activation of FXR Suppresses Esophageal Squamous Cell Carcinoma Through Antagonizing ERK1/2 Signaling Pathway
por: Feng, Qingqing, et al.
Publicado: (2021)

Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
por: Hong, Shangyu, et al.
Publicado: (2018)

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated
por: Halbach, Melanie Vanessa, et al.
Publicado: (2015)

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
por: Xu, Jie, et al.
Publicado: (2017)

Fbxw7 Controls Angiogenesis by Regulating Endothelial Notch Activity
por: Izumi, Nanae, et al.
Publicado: (2012)

Regulation of GSK3β-FBXW7-JUNB Axis
por: Pérez-Benavente, Beatriz, et al.
Publicado: (2013)

FBXW7: a critical tumor suppressor of human cancers
por: Yeh, Chien-Hung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_atgjr3ilakt5hjrii75364jk1v