Cargando…

Shiga Toxin (Stx) Type 1a and Stx2a Translocate through a Three-Layer Intestinal Model

Shiga toxins (Stxs) produced by ingested E. coli can induce hemolytic uremic syndrome after crossing the intact intestinal barrier, entering the bloodstream, and targeting endothelial cells in the kidney. The method(s) by which the toxins reach the bloodstream are not fully defined. Here, we used tw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bova, Rebecca A., Lamont, Andrew C., Picou, Theodore J., Ho, Vincent B., Gilchrist, Kristin H., Melton-Celsa, Angela R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054274/ https://www.ncbi.nlm.nih.gov/pubmed/36977098 http://dx.doi.org/10.3390/toxins15030207

Ejemplares similares

Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing Escherichia coli (STEC) Strain B2F1 in Streptomycin (Str)-Treated Mice
por: McNichol, Beth A., et al.
Publicado: (2021)

Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a
por: Russo, Lisa M., et al.
Publicado: (2016)

Differences in the Shiga Toxin (Stx) 2a Phage Regulatory Switch Region Influence Stx2 Localization and Virulence of Stx-Producing Escherichia coli in Mice
por: Atitkar, Rama R., et al.
Publicado: (2023)

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin
por: Bunger, Joshua C., et al.
Publicado: (2015)

Shiga toxin (Stx) type 2‐induced increase in O‐linked N‐acetyl glucosamine protein modification: a new therapeutic target?
por: Bova, Rebecca A, et al.
Publicado: (2021)

Identification and Characterization of ten Escherichia coli Strains Encoding Novel Shiga Toxin 2 Subtypes, Stx2n as Well as Stx2j, Stx2m, and Stx2o, in the United States
por: Lindsey, Rebecca L., et al.
Publicado: (2023)

Shiga Toxin (Stx) Phage-Encoded Lytic Genes Are Not Required for the Mouse Virulence of O157:H7 Escherichia coli Stx2-Producing Clinical Isolates
por: Atitkar, R. R., et al.
Publicado: (2023)

The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool
por: Hauser, Jocelyn R., et al.
Publicado: (2020)

Promoter Sequence of Shiga Toxin 2 (Stx2) Is Recognized In Vivo, Leading to Production of Biologically Active Stx2
por: Bentancor, Leticia V., et al.
Publicado: (2013)

Prevalence and distribution of the stx(1), stx(2) genes in Shiga toxin producing E. coli (STEC) isolates from cattle
por: Tahamtan, Y, et al.
Publicado: (2010)

Analysis Shiga Toxin-Encoding Bacteriophage in a Rare Strain of Shiga Toxin-Producing Escherichia coli O157:H7 stx2a/stx2c
por: Greig, David R., et al.
Publicado: (2020)

New High-Affinity Monoclonal Antibodies against Shiga Toxin 1 Facilitate the Detection of Hybrid Stx1/Stx2 In Vivo
por: Skinner, Craig, et al.
Publicado: (2014)

Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity
por: Detzner, Johanna, et al.
Publicado: (2021)

Multiplex PCR for the simultaneous detection of the Enterobacterial gene wecA, the Shiga Toxin genes (stx(1) and stx(2)) and the Intimin gene (eae)
por: Anglès d’Auriac, Marc B., et al.
Publicado: (2018)

Shiga toxin (stx) encoding genes in sheep and goats reared in Trinidad and Tobago
por: Persad, Anil K., et al.
Publicado: (2022)

Shiga Toxin, Stx2e, Influences the Activity of Porcine Lymphocytes In Vitro
por: Sperling, Daniel, et al.
Publicado: (2023)

Prevalence, O-genotype and Shiga toxin (Stx) 2 subtype of Stx-producing Escherichia coli strains isolated from Argentinean beef cattle
por: OKUNO, Kentaro, et al.
Publicado: (2021)

Dynamic changes in Shiga toxin (Stx) 1 transducing phage throughout the evolution of O26:H11 Stx-producing Escherichia coli
por: Yano, Bungo, et al.
Publicado: (2023)

Validation of the 3M™ Molecular Detection Assay 2 - STEC Gene Screen (stx) for the Detection of Shiga Toxin Gene (stx1 and/or stx2) in Additional Matrixes: AOAC Performance Tested Method(SM) 071903
por: Rosauer, Micki L, et al.
Publicado: (2022)

Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2
por: Hughes, Anna C., et al.
Publicado: (2019)

Influence of temperature and pH on induction of Shiga toxin Stx1a in Escherichia coli
por: Castro, Vinicius Silva, et al.
Publicado: (2023)

Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains
por: Detzner, Johanna, et al.
Publicado: (2021)

Mechanisms that Determine the Differential Stability of Stx(+) and Stx(−) Lysogens
por: Colon, Michael P., et al.
Publicado: (2016)

Differences in Shiga toxin and phage production among stx(2g)-positive STEC strains
por: Granobles Velandia, Claudia V., et al.
Publicado: (2012)

Comparative Genomics and stx Phage Characterization of LEE-Negative Shiga Toxin-Producing Escherichia coli
por: Steyert, Susan R., et al.
Publicado: (2012)

Development of Monoclonal Antibodies and Immunoassays for Sensitive and Specific Detection of Shiga Toxin Stx2f
por: Skinner, Craig, et al.
Publicado: (2013)

The effect of two ribonucleases on the production of Shiga toxin and stx-bearing bacteriophages in Enterohaemorrhagic Escherichia coli
por: Lodato, Patricia B.
Publicado: (2021)

Scalable Reporter Assays to Analyze the Regulation of stx2 Expression in Shiga Toxin-Producing Enteropathogens
por: Koeppel, Martin B., et al.
Publicado: (2021)

Validation of the 3M™ Molecular Detection Assay 2 - STEC Gene Screen (stx and eae) for the Detection of Shiga Toxin Gene (stx1 and/or stx2) and Intimin Gene (eae): AOAC Performance Tested Method(SM) 071902
por: Rosauer, Micki L, et al.
Publicado: (2022)

Effect of the Food Additives Sodium Citrate and Disodium Phosphate on Shiga Toxin-Producing Escherichia coli and Production of stx-Phages and Shiga toxin
por: Lenzi, Lucas J., et al.
Publicado: (2016)

Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles
por: Detzner, Johanna, et al.
Publicado: (2019)

Characterization of Shiga-toxin producing E.coli (STEC) and enteropathogenic E.coli (EPEC) using multiplex Real-Time PCR assays for stx(1), stx(2), eaeA
por: Abbasi, Pejman, et al.
Publicado: (2014)

Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice
por: Obata, Fumiko, et al.
Publicado: (2015)

Validation of the 3M™ Molecular Detection Assay 2 - STEC Gene Screen (stx) for the Detection of Shiga Toxin Gene (stx1 and/or stx2) in Fresh Raw Ground Beef and Fresh Spinach: AOAC Performance Tested Method(SM) 071903
por: Rosauer, Micki L, et al.
Publicado: (2021)

Validation of the 3M(™) Molecular Detection Assay 2—STEC Gene Screen (stx) for Detection of Shiga Toxin Gene (stx1 and/or stx2) in Dried Cannabis Flower and Dried Hemp Flower: AOAC Performance Tested Method(SM) 071903
por: Rosauer, Micki L, et al.
Publicado: (2022)

Evaluation of Recombinant Forms of the Shiga Toxin Variant Stx2eB Subunit and Non-Toxic Mutant Stx2e as Vaccine Candidates against Porcine Edema Disease
por: SATO, Toshio, et al.
Publicado: (2013)

Mucus-Activatable Shiga Toxin Genotype stx2d in Escherichia coli O157:H7
por: Sánchez, Sergio, et al.
Publicado: (2017)

Biodistribution and elimination kinetics of systemic Stx2 by the Stx2A and Stx2B subunit-specific human monoclonal antibodies in mice
por: Sheoran, Abhineet, et al.
Publicado: (2012)

Detection of stx(1) and stx(2) Genes in Pennsylvanian White-Tailed Deer
por: Kistler, Whitney M., et al.
Publicado: (2011)

Validation of the 3M™ Molecular Detection Assay 2—STEC Gene Screen (stx and eae) for Detection of Shiga Toxin Gene (stx1 and/or stx2) and Intimin Gene (eae) in Dried Cannabis Flower and Dried Hemp Flower: AOAC Performance Tested Method(SM) 071902
por: Rosauer, Micki L, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pvefm1hf2fgha3r1esvu6latb8