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HyperCys: A Structure- and Sequence-Based Predictor of Hyper-Reactive Druggable Cysteines
The cysteine side chain has a free thiol group, making it the amino acid residue most often covalently modified by small molecules possessing weakly electrophilic warheads, thereby prolonging on-target residence time and reducing the risk of idiosyncratic drug toxicity. However, not all cysteines ar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054327/ https://www.ncbi.nlm.nih.gov/pubmed/36983037 http://dx.doi.org/10.3390/ijms24065960 |