Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα

Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural simil...

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Detalles Bibliográficos
Autores principales: Cvijetić, Ilija N., Herlah, Barbara, Marinković, Aleksandar, Perdih, Andrej, Bjelogrlić, Snežana K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054454/
https://www.ncbi.nlm.nih.gov/pubmed/36986441
http://dx.doi.org/10.3390/ph16030341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054454/
https://www.ncbi.nlm.nih.gov/pubmed/36986441
http://dx.doi.org/10.3390/ph16030341

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