Development of the First (18)F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (R)-DOTAGA by DOTA in (R)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biodistribution and µSPECT/CT imaging stud...

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Detalles Bibliográficos
Autores principales: Günther, Thomas, Holzleitner, Nadine, Di Carlo, Daniel, Urtz-Urban, Nicole, Lapa, Constantin, Wester, Hans-Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054553/
https://www.ncbi.nlm.nih.gov/pubmed/36986687
http://dx.doi.org/10.3390/pharmaceutics15030826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054553/
https://www.ncbi.nlm.nih.gov/pubmed/36986687
http://dx.doi.org/10.3390/pharmaceutics15030826

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