Cargando…

Development of the First (18)F-Labeled Radiohybrid-Based Minigastrin Derivative with High Target Affinity and Tumor Accumulation by Substitution of the Chelating Moiety

In order to optimize elevated kidney retention of previously reported minigastrin derivatives, we substituted (R)-DOTAGA by DOTA in (R)-DOTAGA-rhCCK-16/-18. CCK-2R-mediated internalization and affinity of the new compounds were determined using AR42J cells. Biodistribution and µSPECT/CT imaging stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Günther, Thomas, Holzleitner, Nadine, Di Carlo, Daniel, Urtz-Urban, Nicole, Lapa, Constantin, Wester, Hans-Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054553/ https://www.ncbi.nlm.nih.gov/pubmed/36986687 http://dx.doi.org/10.3390/pharmaceutics15030826

Ejemplares similares

Introduction of a SiFA Moiety into the D-Glutamate Chain of DOTA-PP-F11N Results in Radiohybrid-Based CCK-2R-Targeted Compounds with Improved Pharmacokinetics In Vivo
por: Holzleitner, Nadine, et al.
Publicado: (2022)

Investigation of the structure-activity relationship at the N-terminal part of minigastrin analogs
por: Holzleitner, Nadine, et al.
Publicado: (2023)

Synthesis and Preclinical Evaluation of (177)Lu-Labeled Radiohybrid PSMA Ligands for Endoradiotherapy of Prostate Cancer
por: Wurzer, Alexander, et al.
Publicado: (2022)

Radiohybrid Ligands: A Novel Tracer Concept Exemplified by (18)F- or (68)Ga-Labeled rhPSMA Inhibitors
por: Wurzer, Alexander, et al.
Publicado: (2020)

Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue
por: Pfister, Joachim, et al.
Publicado: (2015)

Synthesis and preclinical evaluation of novel (99m)Tc-labeled PSMA ligands for radioguided surgery of prostate cancer
por: Kunert, Jan-Philip, et al.
Publicado: (2023)

The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity
por: Poschenrieder, Andreas, et al.
Publicado: (2016)

A radiohybrid theranostics ligand labeled with fluorine-18 and lutetium-177 for fibroblast activation protein-targeted imaging and radionuclide therapy
por: Yang, Tianhong, et al.
Publicado: (2023)

Oxidant and Antioxidant Effects of Gentisic Acid in a (177)Lu-Labelled  Methionine-Containing Minigastrin Analogue
por: Trindade, Victoria, et al.
Publicado: (2020)

Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617
por: dos Santos, José Carlos, et al.
Publicado: (2022)

Exploiting the Concept of Multivalency with (68)Ga- and (89)Zr-Labelled Fusarinine C-Minigastrin Bioconjugates for Targeting CCK2R Expression
por: Summer, Dominik, et al.
Publicado: (2018)

Effects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs
por: Zavvar, Taraneh Sadat, et al.
Publicado: (2023)

Evaluation of Actinium-225 Labeled Minigastrin Analogue [(225)Ac]Ac-DOTA-PP-F11N for Targeted Alpha Particle Therapy
por: Qin, Yun, et al.
Publicado: (2020)

Stabilization Strategies for Linear Minigastrin Analogues: Further Improvements via the Inclusion of Proline into the Peptide Sequence
por: Klingler, Maximilian, et al.
Publicado: (2020)

Improved Tumor-Targeting with Peptidomimetic Analogs of Minigastrin (177)Lu-PP-F11N
por: Grob, Nathalie M., et al.
Publicado: (2021)

Substitution of l-Tryptophan by α-Methyl-l-Tryptophan in (177)Lu-RM2 Results in (177)Lu-AMTG, a High-Affinity Gastrin-Releasing Peptide Receptor Ligand with Improved In Vivo Stability
por: Günther, Thomas, et al.
Publicado: (2022)

Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor
por: Lipiński, Piotr F. J., et al.
Publicado: (2018)

Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting
por: Klingler, Maximilian, et al.
Publicado: (2018)

The Influence of the Combination of Carboxylate and Phosphinate Pendant Arms in 1,4,7-Triazacyclononane-Based Chelators on Their (68)Ga Labelling Properties
por: Máté, Gábor, et al.
Publicado: (2015)

Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting: Erratum
por: Klingler, Maximilian, et al.
Publicado: (2019)

A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety
por: Elmlund, Louise, et al.
Publicado: (2014)

Modeling framework for isotopic labeling of heteronuclear moieties
por: Borkum, Mark I., et al.
Publicado: (2017)

Chelators in the Treatment of Iron Accumulation in Parkinson's Disease
por: Mounsey, Ross B., et al.
Publicado: (2012)

Cholecystokinin-2 Receptor Targeting with Novel C-terminally Stabilized HYNIC-Minigastrin Analogs Radiolabeled with Technetium-99m
por: Klingler, Maximilian, et al.
Publicado: (2019)

Signaling Network Response to α-Particle–Targeted Therapy with the (225)Ac-Labeled Minigastrin Analog (225)Ac-PP-F11N Reveals the Radiosensitizing Potential of Histone Deacetylase Inhibitors
por: Qin, Yun, et al.
Publicado: (2023)

Equilibrium Thermodynamics, Formation, and Dissociation Kinetics of Trivalent Iron and Gallium Complexes of Triazacyclononane-Triphosphinate (TRAP) Chelators: Unraveling the Foundations of Highly Selective Ga-68 Labeling
por: Vágner, Adrienn, et al.
Publicado: (2018)

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties
por: Ai, Xin, et al.
Publicado: (2016)

Removal of PCR Error Products and Unincorporated Primers by Metal-Chelate Affinity Chromatography
por: Kanakaraj, Indhu, et al.
Publicado: (2011)

Chelating effect in short polymers for the design of bidentate binders of increased affinity and selectivity
por: Fortuna, Sara, et al.
Publicado: (2015)

Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety
por: Shang, Ruofeng, et al.
Publicado: (2013)

High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent
por: Heuberger, Dorothea M., et al.
Publicado: (2019)

From preclinical development to clinical application: Kit formulation for radiolabelling the minigastrin analogue CP04 with In-111 for a first-in-human clinical trial
por: Pawlak, Dariusz, et al.
Publicado: (2016)

Therapeutic Response of CCKBR-Positive Tumors to Combinatory Treatment with Everolimus and the Radiolabeled Minigastrin Analogue [(177)Lu]Lu-PP-F11N
por: Grzmil, Michal, et al.
Publicado: (2021)

P–Ru-Complexes with a Chelate-Bridge-Switch: A Comparison of 2-Picolyl and 2-Pyridyloxy Moieties as Bridging Ligands
por: Ehrlich, Lisa, et al.
Publicado: (2022)

Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes
por: Shaffer, Travis M., et al.
Publicado: (2015)

Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
por: Kluba, Christiane A., et al.
Publicado: (2013)

Antimicrobial effect of para-alkoxyphenylcarbamic acid esters containing substituted N-phenylpiperazine moiety
por: Malík, Ivan, et al.
Publicado: (2013)

Synthesis and antibacterial activity of novel levofloxacin derivatives containing a substituted thienylethyl moiety
por: Mohammadhosseini, Negar, et al.
Publicado: (2012)

Synthesis of Symmetrical Tetrameric Conjugates of the Radiolanthanide Chelator DOTPI for Application in Endoradiotherapy by Means of Click Chemistry
por: Wurzer, Alexander, et al.
Publicado: (2018)

Efficient formation of inert Bi-213 chelates by tetraphosphorus acid analogues of DOTA: towards improved alpha-therapeutics
por: Šimeček, Jakub, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vhf9asdg6pdjoo8jj0k796o6o2