Targeted repression of DNA topoisomerase I by CRISPRi reveals a critical function for it in the Chlamydia trachomatis developmental cycle

Chlamydia trachomatis is an obligate intracellular bacterium that is responsible for the most prevalent bacterial sexually transmitted infections. Changes in DNA topology in this pathogen have been linked to its pathogenicity-associated developmental cycle. Here, evidence is provided that the balanc...

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Detalles Bibliográficos
Autores principales: Shen, Li, Gao, Leiqiong, Swoboda, Abigail R., Ouellette, Scot P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054935/
https://www.ncbi.nlm.nih.gov/pubmed/36993624
http://dx.doi.org/10.1101/2023.03.14.532001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054935/
https://www.ncbi.nlm.nih.gov/pubmed/36993624
http://dx.doi.org/10.1101/2023.03.14.532001

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