Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

Immune evasion is a critical step of cancer progression that remains a major obstacle for current T cell-based immunotherapies. Hence, we seek to genetically reprogram T cells to exploit a common tumor-intrinsic evasion mechanism, whereby cancer cells suppress T cell function by generating a metabol...

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Detalles Bibliográficos
Autores principales: Renauer, Paul, Park, Jonathan J., Bai, Meizhu, Acosta, Arianny, Lee, Won-Ho, Lin, Guang Han, Zhang, Yueqi, Dai, Xiaoyun, Wang, Guangchuan, Errami, Youssef, Wu, Terence, Clark, Paul, Ye, Lupeng, Yang, Quanjun, Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055032/
https://www.ncbi.nlm.nih.gov/pubmed/36993638
http://dx.doi.org/10.1101/2023.03.14.532663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055032/
https://www.ncbi.nlm.nih.gov/pubmed/36993638
http://dx.doi.org/10.1101/2023.03.14.532663

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