Accurate estimation of rare cell type fractions from tissue omics data via hierarchical deconvolution

Bulk transcriptomics in tissue samples reflects the average expression levels across different cell types and is highly influenced by cellular fractions. As such, it is critical to estimate cellular fractions to both deconfound differential expression analyses and infer cell type-specific differenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Penghui, Cai, Manqi, Lu, Xinghua, McKennan, Chris, Wang, Jiebiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055056/
https://www.ncbi.nlm.nih.gov/pubmed/36993280
http://dx.doi.org/10.1101/2023.03.15.532820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055056/
https://www.ncbi.nlm.nih.gov/pubmed/36993280
http://dx.doi.org/10.1101/2023.03.15.532820

Ejemplares similares