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Accurate estimation of rare cell type fractions from tissue omics data via hierarchical deconvolution
Bulk transcriptomics in tissue samples reflects the average expression levels across different cell types and is highly influenced by cellular fractions. As such, it is critical to estimate cellular fractions to both deconfound differential expression analyses and infer cell type-specific differenti...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055056/ https://www.ncbi.nlm.nih.gov/pubmed/36993280 http://dx.doi.org/10.1101/2023.03.15.532820 |