Comparative analysis between single-cell RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise

Stochastic fluctuations (noise) in transcription generate substantial cell-to-cell variability, but the physiological roles of noise have remained difficult to determine in the absence of generalized noise-modulation approaches. Previous single-cell RNA-sequencing (scRNA-seq) suggested that the pyri...

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Detalles Bibliográficos
Autores principales: Calia, Giuliana P., Chen, Xinyue, Zuckerman, Binyamin, Weinberger, Leor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055090/
https://www.ncbi.nlm.nih.gov/pubmed/36993609
http://dx.doi.org/10.1101/2023.03.14.532632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055090/
https://www.ncbi.nlm.nih.gov/pubmed/36993609
http://dx.doi.org/10.1101/2023.03.14.532632

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