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Compartment-Specific Activation of the Proton-Sensor GPR65 is Uncoupled from Receptor Trafficking

The canonical view of G protein-coupled receptor (GPCR) function is that receptor trafficking is tightly coupled to signaling. GPCRs remain on the plasma membrane (PM) at the cell surface until they are activated, after which they are desensitized and internalized into endosomal compartments. This c...

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Detalles Bibliográficos
Autores principales: Rodríguez, Loyda M. Morales, Crilly, Stephanie E., Rowe, Jacob B., Isom, Daniel G., Puthenveedu, Manojkumar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055196/
https://www.ncbi.nlm.nih.gov/pubmed/36993269
http://dx.doi.org/10.1101/2023.03.18.533272