Free ferrous ions sustain activity of mammalian stearoyl-CoA desaturase-1

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Mammalian stearoyl-CoA desaturase-1 (SCD1) introduces a double-bond to a saturated long-chain fatty acid and the reaction is catalyzed by a diiron center, which is well-coordinated by conserved histidine residues and is thought to remain with enzyme. However, we find that SCD1 progressively loses it...

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Detalles Bibliográficos
Autores principales: Shen, Jiemin, Wu, Gang, Pierce, Brad S., Tsai, Ah-Lim, Zhou, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055294/
https://www.ncbi.nlm.nih.gov/pubmed/36993326
http://dx.doi.org/10.1101/2023.03.17.533000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055294/
https://www.ncbi.nlm.nih.gov/pubmed/36993326
http://dx.doi.org/10.1101/2023.03.17.533000

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