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FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development
FGF activation is known to engage canonical signals, including ERK/MAPK and PI3K/AKT, through various effectors including FRS2 and GRB2. Fgfr2(FCPG/FCPG) mutants that abrogate canonical intracellular signaling exhibit a range of mild phenotypes but are viable in contrast to embryonic lethal Fgfr2(−/...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055321/ https://www.ncbi.nlm.nih.gov/pubmed/36993499 http://dx.doi.org/10.1101/2023.03.23.534012 |