Utilizing Estra-1,3,5,16-Tetraene Scaffold: Design and Synthesis of Nitric Oxide Donors as Chemotherapeutic Resistance Combating Agents in Liver Cancer

A new series of nitric oxide-releasing estra-1,3,5,16-tetraene analogs (NO-∆-16-CIEAs) was designed and synthesized as dual inhibitors for EGFR and MRP2 based on our previous findings on estra-1,3,5-triene analog NO-CIEA 17 against both HepG2 and HepG2-R cell lines. Among the target compounds, 14a (...

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Detalles Bibliográficos
Autores principales: Abou-Salim, Mahrous A., Shaaban, Mohamed A., Abd El Hameid, Mohammed K., Alanazi, Mohammed M., Halaweish, Fathi, Elshaier, Yaseen A. M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055446/
https://www.ncbi.nlm.nih.gov/pubmed/36985726
http://dx.doi.org/10.3390/molecules28062754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055446/
https://www.ncbi.nlm.nih.gov/pubmed/36985726
http://dx.doi.org/10.3390/molecules28062754

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