Statistical Challenges when Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials

Most clinical trials evaluating COVID-19 therapeutics include assessments of antiviral activity. In recently completed outpatient trials, changes in nasal SARS-CoV-2 RNA levels from baseline were commonly assessed using analysis of covariance (ANCOVA) or mixed models for repeated measures (MMRM) wit...

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Detalles Bibliográficos
Autores principales: Moser, Carlee B, Chew, Kara W, Giganti, Mark J, Li, Jonathan Z, Aga, Evgenia, Ritz, Justin, Greninger, Alexander L, Javan, Arzhang Cyrus, Daar, Eric S, Currier, Judith S, Eron, Joseph J, Smith, Davey M, Hughes, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055451/
https://www.ncbi.nlm.nih.gov/pubmed/36993419
http://dx.doi.org/10.1101/2023.03.13.23287208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055451/
https://www.ncbi.nlm.nih.gov/pubmed/36993419
http://dx.doi.org/10.1101/2023.03.13.23287208

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