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Rapid emergence and transmission of virulence-associated mutations in the oral poliovirus vaccine following vaccination campaigns

There is an increasing burden of circulating vaccine-derived polioviruses (cVDPVs) due to the continued use of oral poliovirus vaccine (OPV). However, the informativeness of routine OPV VP1 sequencing for the early identification of viruses carrying virulence-associated reversion mutations has not b...

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Detalles Bibliográficos
Autores principales: Walter, Katharine S., Altamirano, Jonathan, Huang, ChunHong, Carrington, Yuan J., Zhou, Frank, Andrews, Jason R., Maldonado, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055580/
https://www.ncbi.nlm.nih.gov/pubmed/36993386
http://dx.doi.org/10.1101/2023.03.16.23287381