Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53

O-GlcNAcase (OGA) is the sole enzyme that hydrolyzes O-GlcNAcylation from thousands of proteins and is dysregulated in many diseases including cancer. However, the substrate recognition and pathogenic mechanisms of OGA remain largely unknown. Here we report the first discovery of a cancer-derived po...

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Detalles Bibliográficos
Autores principales: Hu, Chia-Wei, Wang, Ao, Fan, Dacheng, Worth, Matthew, Chen, Zhengwei, Huang, Junfeng, Xie, Jinshan, Macdonald, John, Li, Lingjun, Jiang, Jiaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055641/
https://www.ncbi.nlm.nih.gov/pubmed/36993758
http://dx.doi.org/10.21203/rs.3.rs-2709128/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055641/
https://www.ncbi.nlm.nih.gov/pubmed/36993758
http://dx.doi.org/10.21203/rs.3.rs-2709128/v1

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