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Formal synthesis of kibdelomycin and derivatisation of amycolose glycosides

A convergent total synthesis of bacterial gyrase B/topoisomerase IV inhibitor kibdelomycin (a.k.a. amycolamicin) (1) was devised starting from inexpensive d-mannose and l-rhamnose, which were converted in new efficient ways to an N-acylated amycolose and an amykitanose derivative as late building bl...

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Detalles Bibliográficos
Autores principales: Schriefer, Manuel G., Treiber, Laura, Schobert, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055692/
https://www.ncbi.nlm.nih.gov/pubmed/37006682
http://dx.doi.org/10.1039/d3sc00595j