Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

The overexpression of aberrantly glycosylated tumor-associated mucin-1 (TA-MUC1) in human cancers makes it a major target for the development of anticancer vaccines derived from synthetic MUC1-(glyco)peptide antigens. However, glycopeptide-based subunit vaccines are weakly immunogenic, requiring adj...

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Detalles Bibliográficos
Autores principales: Pifferi, Carlo, Aguinagalde, Leire, Ruiz-de-Angulo, Ane, Sacristán, Nagore, Baschirotto, Priscila Tonon, Poveda, Ana, Jiménez-Barbero, Jesús, Anguita, Juan, Fernández-Tejada, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055764/
https://www.ncbi.nlm.nih.gov/pubmed/37006677
http://dx.doi.org/10.1039/d2sc05639a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055764/
https://www.ncbi.nlm.nih.gov/pubmed/37006677
http://dx.doi.org/10.1039/d2sc05639a

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