Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-...

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Autores principales: Freiberg, Kaitlyn M., Kavthe, Rahul D., Thomas, Rohan M., Fialho, David M., Dee, Paris, Scurria, Matthew, Lipshutz, Bruce H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055766/
https://www.ncbi.nlm.nih.gov/pubmed/37006678
http://dx.doi.org/10.1039/d3sc00198a
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author Freiberg, Kaitlyn M.
Kavthe, Rahul D.
Thomas, Rohan M.
Fialho, David M.
Dee, Paris
Scurria, Matthew
Lipshutz, Bruce H.
author_facet Freiberg, Kaitlyn M.
Kavthe, Rahul D.
Thomas, Rohan M.
Fialho, David M.
Dee, Paris
Scurria, Matthew
Lipshutz, Bruce H.
author_sort Freiberg, Kaitlyn M.
collection PubMed
description Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality.
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spelling pubmed-100557662023-03-30 Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green Freiberg, Kaitlyn M. Kavthe, Rahul D. Thomas, Rohan M. Fialho, David M. Dee, Paris Scurria, Matthew Lipshutz, Bruce H. Chem Sci Chemistry Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality. The Royal Society of Chemistry 2023-02-28 /pmc/articles/PMC10055766/ /pubmed/37006678 http://dx.doi.org/10.1039/d3sc00198a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Freiberg, Kaitlyn M.
Kavthe, Rahul D.
Thomas, Rohan M.
Fialho, David M.
Dee, Paris
Scurria, Matthew
Lipshutz, Bruce H.
Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title_full Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title_fullStr Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title_full_unstemmed Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title_short Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
title_sort direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055766/
https://www.ncbi.nlm.nih.gov/pubmed/37006678
http://dx.doi.org/10.1039/d3sc00198a
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