Current Status of Oligonucleotide-Based Protein Degraders

Transcription factors (TFs) and RNA-binding proteins (RBPs) have long been considered undruggable, mainly because they lack ligand-binding sites and are equipped with flat and narrow protein surfaces. Protein-specific oligonucleotides have been harnessed to target these proteins with some satisfacto...

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Detalles Bibliográficos
Autores principales: Shih, Po-Chang, Naganuma, Miyako, Demizu, Yosuke, Naito, Mikihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055846/
https://www.ncbi.nlm.nih.gov/pubmed/36986626
http://dx.doi.org/10.3390/pharmaceutics15030765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055846/
https://www.ncbi.nlm.nih.gov/pubmed/36986626
http://dx.doi.org/10.3390/pharmaceutics15030765

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