In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline-O-Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites

The effects of decoquinate (DCQ) and three O-quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with Neospora caninum tachyzoites. These compounds exhibited half-maximal proliferation inhibition (IC(50)s) from 1.7 (RMB060) to 60 nM (RMB055). Conversely,...

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Detalles Bibliográficos
Autores principales: Ramseier, Jessica, Imhof, Dennis, Hänggeli, Kai Pascal Alexander, Anghel, Nicoleta, Boubaker, Ghalia, Beteck, Richard M., Ortega-Mora, Luis-Miguel, Haynes, Richard K., Hemphill, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055983/
https://www.ncbi.nlm.nih.gov/pubmed/36986369
http://dx.doi.org/10.3390/pathogens12030447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055983/
https://www.ncbi.nlm.nih.gov/pubmed/36986369
http://dx.doi.org/10.3390/pathogens12030447

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