Identification of Blood Transport Proteins to Carry Temoporfin: A Domino Approach from Virtual Screening to Synthesis and In Vitro PDT Testing

Temoporfin (mTHPC) is one of the most promising photosensitizers used in photodynamic therapy (PDT). Despite its clinical use, the lipophilic character of mTHPC still hampers the full exploitation of its potential. Low solubility in water, high tendency to aggregate, and low biocompatibility are the...

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Detalles Bibliográficos
Autores principales: Marconi, Alessia, Giugliano, Giulia, Di Giosia, Matteo, Marforio, Tainah Dorina, Trivini, Michele, Turrini, Eleonora, Fimognari, Carmela, Zerbetto, Francesco, Mattioli, Edoardo Jun, Calvaresi, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056000/
https://www.ncbi.nlm.nih.gov/pubmed/36986780
http://dx.doi.org/10.3390/pharmaceutics15030919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056000/
https://www.ncbi.nlm.nih.gov/pubmed/36986780
http://dx.doi.org/10.3390/pharmaceutics15030919

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