Supermolecule—Drug Conjugates Based on Acid-Degradable Polyrotaxanes for pH-Dependent Intracellular Release of Doxorubicin

Doxorubicin (DOX)-conjugated acid-degradable polyrotaxanes (PRXs) were designed as supramolecular drug carriers capable of releasing drugs in acidic cellular environments. Acid-degradable PRXs composed of α-cyclodextrin (α-CD) as a cyclic molecule, poly(ethylene glycol) (PEG) as a polymer axis, and...

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Detalles Bibliográficos
Autores principales: Tamura, Atsushi, Osawa, Mamoru, Yui, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056152/
https://www.ncbi.nlm.nih.gov/pubmed/36985487
http://dx.doi.org/10.3390/molecules28062517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056152/
https://www.ncbi.nlm.nih.gov/pubmed/36985487
http://dx.doi.org/10.3390/molecules28062517

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