Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma

Chimeric antigen receptor (CAR)-T cells, a therapeutic agent for solid tumors, are not completely effective due to a lack of infiltration of T cells into the tumor site and immunity caused by Programmed Death Receptor 1(PD1). Here, an epidermal growth factor receptor (EGFR) CAR-T cell was engineered...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jing, Wang, Yanan, Pan, Hanyu, Zhao, Lin, Yang, Xinyi, Liang, Zhiming, Shen, Xiaoting, Zhang, Jing, Yang, Jinlong, Zhu, Yuqi, Xun, Jingna, Liang, Yue, Lin, Qinru, Liang, Huitong, Li, Min, Zhu, Huanzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056525/
https://www.ncbi.nlm.nih.gov/pubmed/36982500
http://dx.doi.org/10.3390/ijms24065424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056525/
https://www.ncbi.nlm.nih.gov/pubmed/36982500
http://dx.doi.org/10.3390/ijms24065424

Ejemplares similares