pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

Drug degradation at low pH and rapid clearance from intestinal absorption sites are the main factors limiting the development of oral macromolecular delivery systems. Based on the pH responsiveness and mucosal adhesion of hyaluronic acid (HA) and poly[2-(dimethylamino)ethyl methacrylate] (PDM), we p...

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Detalles Bibliográficos
Autores principales: Wang, Shuangqing, Meng, Saige, Zhou, Xinlei, Gao, Zhonggao, Piao, Ming Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056758/
https://www.ncbi.nlm.nih.gov/pubmed/36986680
http://dx.doi.org/10.3390/pharmaceutics15030820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056758/
https://www.ncbi.nlm.nih.gov/pubmed/36986680
http://dx.doi.org/10.3390/pharmaceutics15030820

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