Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43

It is known that the spike protein of human coronaviruses can bind to a secondary receptor, or coreceptor, to facilitate the virus entry. While HCoV-229E uses human aminopeptidase N (hAPN) as a receptor, HCoV-OC43 binds to 9-O-acetyl-sialic acid (9-O-Ac-Sia), which is linked in a terminal way to the...

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Detalles Bibliográficos
Autores principales: Fuochi, Virginia, Floresta, Giuseppe, Emma, Rosalia, Patamia, Vincenzo, Caruso, Massimo, Zagni, Chiara, Ronchi, Federica, Ronchi, Celestino, Drago, Filippo, Rescifina, Antonio, Furneri, Pio Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056857/
https://www.ncbi.nlm.nih.gov/pubmed/36992372
http://dx.doi.org/10.3390/v15030663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056857/
https://www.ncbi.nlm.nih.gov/pubmed/36992372
http://dx.doi.org/10.3390/v15030663

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