Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss

Cyclin D1 is a regulatory subunit of cyclin-Dependent Kinases 4 and 6 (CDK4/6) and regulates progression from G1 to S phase of the cell cycle. Dysregulated cyclin D1-CDK4/6 contributes to abnormal cell proliferation and tumor development. Phosphorylation of threonine 286 of cyclin D1 is necessary fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshida, Akihiro, Phillips-Mason, Polly, Tarallo, Vincenzo, Avril, Stefanie, Koivisto, Christopher, Leone, Gustavo, Diehl, J. Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056880/
https://www.ncbi.nlm.nih.gov/pubmed/35210557
http://dx.doi.org/10.1038/s41388-022-02243-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056880/
https://www.ncbi.nlm.nih.gov/pubmed/35210557
http://dx.doi.org/10.1038/s41388-022-02243-8

Ejemplares similares