Cargando…

Non-phosphorylatable cyclin D1 mutant potentiates endometrial hyperplasia and drives carcinoma with Pten loss

Cyclin D1 is a regulatory subunit of cyclin-Dependent Kinases 4 and 6 (CDK4/6) and regulates progression from G1 to S phase of the cell cycle. Dysregulated cyclin D1-CDK4/6 contributes to abnormal cell proliferation and tumor development. Phosphorylation of threonine 286 of cyclin D1 is necessary fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshida, Akihiro, Phillips-Mason, Polly, Tarallo, Vincenzo, Avril, Stefanie, Koivisto, Christopher, Leone, Gustavo, Diehl, J. Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056880/ https://www.ncbi.nlm.nih.gov/pubmed/35210557 http://dx.doi.org/10.1038/s41388-022-02243-8

Ejemplares similares

Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax
por: Simonyan, Lilit, et al.
Publicado: (2023)

WWP2 and its association with PTEN in endometrial cancer
por: Clements, Aine E., et al.
Publicado: (2015)

PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women
por: Gbelcová, H., et al.
Publicado: (2015)

The PTEN, BAX, and IGFIIR Genes Are Mutated in Endometrial Atypical Hyperplasia
por: Yoshinaga, Kousuke, et al.
Publicado: (1998)

Structural characterizations of phosphorylatable residues in transmembrane proteins from Arabidopsis thaliana
por: Xue, Bin, et al.
Publicado: (2013)

Threonine 89 Is an Important Residue of Profilin-1 That Is Phosphorylatable by Protein Kinase A
por: Gau, David, et al.
Publicado: (2016)

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities
por: Terakawa, Jumpei, et al.
Publicado: (2019)

Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin
por: Dilruba, Shahana, et al.
Publicado: (2020)

Impact of phosphomimetic and non-phosphorylatable mutations of phospholemman on L-type calcium channels gating in HEK 293T cells
por: Guo, Kai, et al.
Publicado: (2015)

A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma
por: Gendron, David R., et al.
Publicado: (2017)

PTEN mutation predicts unfavorable fertility preserving treatment outcome in the young patients with endometrioid endometrial cancer and atypical hyperplasia
por: Xue, Yu, et al.
Publicado: (2023)

Utility of p63 and PTEN staining in distinguishing cervical microglandular hyperplasia from endometrial endometrioid carcinoma with microglandular/mucinous features
por: Aoun, Batoul A., et al.
Publicado: (2022)

Endometrial hyperplasia as a risk factor of endometrial cancer
por: Nees, Lisa K., et al.
Publicado: (2022)

Effects of Phosphorylatable Short Peptide-Conjugated Chitosan-Mediated IL-1Ra and igf-1 Gene Transfer on Articular Cartilage Defects in Rabbits
por: Zhao, Ronglan, et al.
Publicado: (2014)

Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis
por: Lin, Xue, et al.
Publicado: (2023)

The PTENP1 Pseudogene, Unlike the PTEN Gene, Is Methylated in Normal Endometrium, As Well As in Endometrial Hyperplasias and Carcinomas in Middle-Aged and Elderly Females
por: Kovalenko, T. F., et al.
Publicado: (2018)

Endometrial Stromal Hyperplasia: An Underrecognized Condition
por: Sivridis, Efthimios, et al.
Publicado: (2013)

Genomic imbalance in endometrial hyperplasia and cancer
por: Bednarek, Michal, et al.
Publicado: (2015)

Therapeutic options for management of endometrial hyperplasia
por: Chandra, Vishal, et al.
Publicado: (2016)

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten
por: Liang, Xiaohuan, et al.
Publicado: (2018)

Expression of the VEGF and angiopoietin genes in endometrial atypical hyperplasia and endometrial cancer
por: Holland, C M, et al.
Publicado: (2003)

Progestin Resistance and Corresponding Management of Abnormal Endometrial Hyperplasia and Endometrial Carcinoma
por: Lv, Mu, et al.
Publicado: (2022)

Rapid identification of endometrial hyperplasia and endometrial endometrioid cancer in young women
por: Kuai, Dan, et al.
Publicado: (2023)

Role of Cyclin-Dependent Kinase Inhibitors in Endometrial Cancer
por: Giannone, Gaia, et al.
Publicado: (2019)

Steroid Hormone Intervenes in the Endometrial Tumorigenesis of Pten Ablation
por: Kim, Hong Im, et al.
Publicado: (2013)

Metformin for endometrial hyperplasia: a Cochrane protocol
por: Clement, Naomi S, et al.
Publicado: (2016)

Lymph node dissection in atypical endometrial hyperplasia
por: Taşkın, Salih, et al.
Publicado: (2017)

The value of MRI in management of endometrial hyperplasia with atypia
por: Natarajan, Purushothaman, et al.
Publicado: (2020)

The Value of Vaginal Microbiome in Patients with Endometrial Hyperplasia
por: Zhang, Hu, et al.
Publicado: (2021)

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer
por: Sun, Yizhe, et al.
Publicado: (2021)

Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3
por: Yoshida, Akihiro, et al.
Publicado: (2020)

Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms
por: Liu, Ying, et al.
Publicado: (2016)

Risk factors of endometrial cancer in patients with endometrial hyperplasia: implication for clinical treatments
por: Zhao, Jie, et al.
Publicado: (2021)

Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity
por: Chen, Junyu, et al.
Publicado: (2022)

Laparoscopic Surgery for Atypical Endometrial Hyperplasia with Awareness Regarding the Possibility of Endometrial Cancer
por: Kamii, Misato, et al.
Publicado: (2022)

PTEN Redundancy: Overexpressing lpten, a Homolog of Dictyostelium discoideum ptenA, the Ortholog of Human PTEN, Rescues All Behavioral Defects of the Mutant ptenA(−)
por: Lusche, Daniel F., et al.
Publicado: (2014)

Neurovascular Development in Pten and Tsc2 Mouse Mutants
por: Dusing, Mary, et al.
Publicado: (2023)

A Case of Cushing's Syndrome Presenting as Endometrial Hyperplasia
por: Lee, Sang Min, et al.
Publicado: (2008)

Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia
por: Cakmak, Bulent, et al.
Publicado: (2015)

New concepts for an old problem: the diagnosis of endometrial hyperplasia
por: Sanderson, Peter A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_s4tp6gv9gs4es0ffmg455258dj