Mechanism of Chiral-Selective Aminoacylation of an RNA Minihelix Explored by QM/MM Free-Energy Simulations

Aminoacylation of a primordial RNA minihelix composed of D-ribose shows L-amino acid preference over D-amino acid without any ribozymes or enzymes. This preference in the amino acylation reaction likely plays an important role in the establishment of homochirality in L-amino acid in modern proteins....

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Detalles Bibliográficos
Autores principales: Ando, Tadashi, Tamura, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057131/
https://www.ncbi.nlm.nih.gov/pubmed/36983877
http://dx.doi.org/10.3390/life13030722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057131/
https://www.ncbi.nlm.nih.gov/pubmed/36983877
http://dx.doi.org/10.3390/life13030722

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