One-Pot Synthesis of Isoxazole-Fused Tricyclic Quinazoline Alkaloid Derivatives via Intramolecular Cycloaddition of Propargyl-Substituted Methyl Azaarenes under Metal-Free Conditions

A practical method was developed for the convenient synthesis of isoxazole-fused tricyclic quinazoline alkaloids. This procedure accesses diverse isoxazole-fused tricyclic quinazoline alkaloids and their derivatives via intramolecular cycloaddition of methyl azaarenes with tert-butyl nitrite (TBN)....

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Detalles Bibliográficos
Autores principales: Wang, Zhuo, Zhao, Yuhan, Chen, Jiaxin, Chen, Mengyao, Li, Xuehan, Jiang, Ting, Liu, Fang, Yang, Xi, Sun, Yuanyuan, Zhu, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057414/
https://www.ncbi.nlm.nih.gov/pubmed/36985760
http://dx.doi.org/10.3390/molecules28062787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057414/
https://www.ncbi.nlm.nih.gov/pubmed/36985760
http://dx.doi.org/10.3390/molecules28062787

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