Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Compounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the antagonistic activity, we describe herein the synthes...

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Detalles Bibliográficos
Autores principales: Finamore, Claudia, Festa, Carmen, Fiorillo, Bianca, Leva, Francesco Saverio Di, Roselli, Rosalinda, Marchianò, Silvia, Biagioli, Michele, Spinelli, Lucio, Fiorucci, Stefano, Limongelli, Vittorio, Zampella, Angela, De Marino, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057480/
https://www.ncbi.nlm.nih.gov/pubmed/36985811
http://dx.doi.org/10.3390/molecules28062840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057480/
https://www.ncbi.nlm.nih.gov/pubmed/36985811
http://dx.doi.org/10.3390/molecules28062840

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