Trypanosoma cruzi Sirtuin 2 as a Relevant Druggable Target: New Inhibitors Developed by Computer-Aided Drug Design

Trypanosoma cruzi, the etiological agent of Chagas disease, relies on finely coordinated epigenetic regulation during the transition between hosts. Herein we targeted the silent information regulator 2 (Sir2) enzyme, a NAD(+)-dependent class III histone deacetylase, to interfere with the parasites’...

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Detalles Bibliográficos
Autores principales: Ferreira, Glaucio Monteiro, Kronenberger, Thales, Maltarollo, Vinicius Gonçalves, Poso, Antti, de Moura Gatti, Fernando, Almeida, Vitor Medeiros, Marana, Sandro Roberto, Lopes, Carla Duque, Tezuka, Daiane Yukie, de Albuquerque, Sérgio, da Silva Emery, Flavio, Trossini, Gustavo Henrique Goulart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057528/
https://www.ncbi.nlm.nih.gov/pubmed/36986527
http://dx.doi.org/10.3390/ph16030428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057528/
https://www.ncbi.nlm.nih.gov/pubmed/36986527
http://dx.doi.org/10.3390/ph16030428

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