LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells

SARS-CoV-2 sequences can be reverse-transcribed and integrated into the genomes of virus-infected cells by a LINE1-mediated retrotransposition mechanism. Whole-genome sequencing (WGS) methods detected retrotransposed SARS-CoV-2 subgenomic sequences in virus-infected cells overexpressing LINE1, while...

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Detalles Bibliográficos
Autores principales: Zhang, Liguo, Bisht, Punam, Flamier, Anthony, Barrasa, M. Inmaculada, Friesen, Max, Richards, Alexsia, Hughes, Stephen H., Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057545/
https://www.ncbi.nlm.nih.gov/pubmed/36992338
http://dx.doi.org/10.3390/v15030629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057545/
https://www.ncbi.nlm.nih.gov/pubmed/36992338
http://dx.doi.org/10.3390/v15030629

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