Auranofin Targeting the NDM-1 Beta-Lactamase: Computational Insights into the Electronic Configuration and Quasi-Tetrahedral Coordination of Gold Ions

Recently, the well-characterized metallodrug auranofin has been demonstrated to restore the penicillin and cephalosporin sensitivity in resistant bacterial strains via the inhibition of the NDM-1 beta-lactamase, which is operated via the Zn/Au substitution in its bimetallic core. The resulting unusu...

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Detalles Bibliográficos
Autores principales: Tolbatov, Iogann, Marrone, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057648/
https://www.ncbi.nlm.nih.gov/pubmed/36986846
http://dx.doi.org/10.3390/pharmaceutics15030985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057648/
https://www.ncbi.nlm.nih.gov/pubmed/36986846
http://dx.doi.org/10.3390/pharmaceutics15030985

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