Design Considerations for Intratracheal Delivery Devices to Achieve Proof-of-Concept Dry Powder Biopharmaceutical Delivery in Mice

PURPOSE: Intratracheal delivery and consistent dosing of dry powder vaccines is especially challenging in mice. To address this issue, device design of positive pressure dosators and actuation parameters were assessed for their impacts on powder flowability and in vivo dry powder delivery. METHODS:...

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Detalles Bibliográficos
Autores principales: Manser, Myla, Jeyanathan, Vidthiya, Jeyanathan, Mangalakumari, Feng, Xueya, Dolovich, Myrna B., Xing, Zhou, Cranston, Emily D., Thompson, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057681/
https://www.ncbi.nlm.nih.gov/pubmed/36991226
http://dx.doi.org/10.1007/s11095-023-03492-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057681/
https://www.ncbi.nlm.nih.gov/pubmed/36991226
http://dx.doi.org/10.1007/s11095-023-03492-2

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