TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A

A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk factor for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The accumulation of cryptic UNC13A in di...

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Detalles Bibliográficos
Autores principales: Koike, Yuka, Pickles, Sarah, Estades Ayuso, Virginia, Jansen-West, Karen, Qi, Yue A., Li, Ziyi, Daughrity, Lillian M., Yue, Mei, Zhang, Yong-Jie, Cook, Casey N., Dickson, Dennis W., Ward, Michael, Petrucelli, Leonard, Prudencio, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057836/
https://www.ncbi.nlm.nih.gov/pubmed/36930682
http://dx.doi.org/10.1371/journal.pbio.3002028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057836/
https://www.ncbi.nlm.nih.gov/pubmed/36930682
http://dx.doi.org/10.1371/journal.pbio.3002028

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