Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability

(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10(−6) cm/s across Caco-2 colonic cells), thus resulting in a...

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Detalles Bibliográficos
Autores principales: Lee, Juseung, Lee, Jong-Ju, Lee, Seungyeol, Dinh, Linh, Oh, Hangyu, Abuzar, Sharif Md, Ahn, Jun-Hyun, Hwang, Sung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057842/
https://www.ncbi.nlm.nih.gov/pubmed/36986767
http://dx.doi.org/10.3390/pharmaceutics15030907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057842/
https://www.ncbi.nlm.nih.gov/pubmed/36986767
http://dx.doi.org/10.3390/pharmaceutics15030907

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