Cargando…
Preparation of Apixaban Solid Dispersion for the Enhancement of Apixaban Solubility and Permeability
(1) Background: Solid dispersion (SD) can help increase the bioavailability of poorly water-soluble drugs. Meanwhile, apixaban (APX)—a new anticoagulation drug—has low water solubility (0.028 mg/mL) and low intestinal permeability (0.9 × 10(−6) cm/s across Caco-2 colonic cells), thus resulting in a...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057842/ https://www.ncbi.nlm.nih.gov/pubmed/36986767 http://dx.doi.org/10.3390/pharmaceutics15030907 |