TXNIP loss expands Myc-dependent transcriptional programs by increasing Myc genomic binding

The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expression of thioredoxin interacting protein (TXNIP),...

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Detalles Bibliográficos
Autores principales: Lim, Tian-Yeh, Wilde, Blake R., Thomas, Mallory L., Murphy, Kristin E., Vahrenkamp, Jeffery M., Conway, Megan E., Varley, Katherine E., Gertz, Jason, Ayer, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058090/
https://www.ncbi.nlm.nih.gov/pubmed/36930677
http://dx.doi.org/10.1371/journal.pbio.3001778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058090/
https://www.ncbi.nlm.nih.gov/pubmed/36930677
http://dx.doi.org/10.1371/journal.pbio.3001778

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