The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma

MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-d...

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Detalles Bibliográficos
Autores principales: Wang, Donghai, Yin, Zhinang, Wang, Honghong, Wang, Liyuan, Li, Tianyu, Xiao, Ruijing, Xie, Ting, Han, Ruyi, Dong, Rui, Liu, Hudan, Liang, Kaiwei, Qing, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058231/
https://www.ncbi.nlm.nih.gov/pubmed/36989355
http://dx.doi.org/10.1126/sciadv.adf0005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10058231/
https://www.ncbi.nlm.nih.gov/pubmed/36989355
http://dx.doi.org/10.1126/sciadv.adf0005

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